ICSI Fertilization: The difference from IVF and how is it done?

Every year, there is an increasing number of couples around the world, who cannot become parents for medical reasons. The active development of medicine and the constant introduction of modern scientific research has allowed doctors to create various techniques of artificial insemination, thanks to which the diagnosis of "infertility" has ceased to be the final verdict. Today, different methods of fertilization have become available for infertile couples, they are- IVF, ICSI, GIFT, etc., which to choose, depends fully on the existing pathologies. You can find out what ICSI is in gynecology, with the help of a detailed study of this method of artificial insemination.

Indications for the use of the ICSI procedure

Not all the patients of the family planning centers know what ICSI is. In gynecology, this procedure is given the following definition - intracytoplasmic sperm injection. The main indication for the use/implementation of ICSI fertilization is any form of male infertility, which cannot be medically treated, such as:

  • azoospermia (absence of sperm in the semen);
  • oligoasthenospermia (the presence of a small number of spermatozoa within the semen that move along a straight path);
  • teratospermia (presence of sperm with morphological abnormalities within the semen);
  • acrosome is completely absent in the sperm (or their structure is broken), and so on and so forth;

about how is ICSI performed in detail can be found out from the attending physicians of the FPC, who observe sterile couples. This method of artificial insemination can be activated just once, and bring a positive result, and at the same time can be done many times (until eventual pregnancy).

Preparation for the ICSI procedure

Before performing the ICSI procedure the man and the woman need to carefully prepare for it. First, the partners must undergo laboratory examination, for which they need to pass a series of tests to identify and detect:

  • Rh factor (done once);
  • Blood group;
  • sexually transmitted and infectious diseases (AIDS, syphilis, hepatitis "B", "C", etc...);
  • hormonal status (prolactin, FSH, estradiol, TSH, progesterone, LH, testosterone, etc...);
  • Before ICSI fertilization a swab is taken from the woman’s genital tract, allowing to reveal latent infections, and to determine the state of the microflora. Also, mandatory for IVF and ICSI is the sampling of:
  • urine;
  • blood (for biochemical and clinical analysis);
  • Blood for coagulation (estimation of clotting);

Men before ICSI, should also be examined and apart from the blood samples have to also do a semen analysis. Test results will be valid for 3 months.

How is the ICSI procedure performed

How is ICSI performed in specialized medical institutions? Carrying out the ICSI procedure is possible only after receiving the results with no contraindications after a thorough examination of both the partners. Almost right before the procedure, ovarian stimulation is performed on the woman (for this purpose hormonal medications are appointed). The most viable and active sperms are selected and taken from the man and placed in a special environment in which sterility and a certain temperature range are maintained.

What is the difference between ICSI and IVF? The main difference of the ICSI method is the method of insemination. The job of the embryologist is to insert the selected sperm with the utmost caution into the prepared egg. After this procedure, the woman should be under medical supervision throughout the whole pregnancy. In most cases, successful cell division is observed in the patients, and the long-awaited pregnancy arrives. Therefore, ICSI has only positive reviews.

What can affect the efficiency of the ICSI procedure

Despite the fact that IVF and ICSI have positive reviews, there are factors that can affect the outcome. Higher probability of successful conception is for those women who have healthy gametal cells. Positive feedback is left about ICSI by patients who met the following criteria:

  • do not have genetic abnormalities;
  • are of childbearing age;
  • have normal hormones;
  • do not have a serious illness that caused infertility and so on.


Main difference of IVF from ICSI - is the procedure of conception itself

During the IVF procedure, the egg taken from the woman through a puncture and the sperm are both outside the patient's body (in a test tube), conception occurs in free mode, ie, the strongest of the sperm fertilizes the egg. But the male gamete cells are not always able to carry out their functions. A small number of high-quality sperm in the semen, the pathology of their structure, and even the complete absence of sperm in the ejaculate - there are lots of conditions under which the sperm of the man are not suitable for fertilization. That’s where reproductive technologies come to the aid.

Thinking of a way of artificial insemination, infertile couples often ask the question: How is ICSI different from IVF? These two procedures are similar in many respects:

  • in the process of the examination of the partners;
  • The requirements for men and women's health;
  • The principle of stimulation of gametal cells and so on.

The difference between IVF and ICSI is in the process of fertilization. During In vitro fertilization, the mature egg is extracted from the ovaries and is fertilized in the laboratory by the most active sperm. After that, the embryos (usually a few of them) are transplanted into the woman's uterus and then one only needs to wait for the walls to heal.

During ICSI, a sperm is inserted into the woman by an injection (without removing the egg). Such a procedure is possible only if the woman has healthy and fully passable, fallopian tubes.

The essential difference between IVF and ICSI is in the cost of the in vitro fertilization procedures. In vitro fertilization entails considerable financial costs for examination, the hormonal stimulation, embryo planting, etc...

Despite the existing differences between the techniques of artificial fertilization, the majority of infertile women, leave only positive feedback after treatment, whether it was IVF or ICSI. This is because with their help, they received a long-awaited chance to become happy parents.