Saint-Petersburg

13th line of Vasilevsky Island, 10
Vasileostrovskaya station

Moscow

Verkhnyaya Krasnoselskaya, 3/3
Krasnoselskaya

8 (812) 77 55555

7 (495) 111 0909

Encyclopaedia

Everything you wanted to know about REPRODUCTION METHODS

Prenatal DNA screening

Х Opportunity:  to exclude the Down's syndrome and other chromosomal abnormalities

Х Safety:  of the mother and the fetus – “non-invasive”

Х High Priority: from 9 weeks of pregnancy

Х Accuracy: research of the DNA with a probability of 99.7%

Х Efficiency – just one phase –only through a blood test

Х  Individuality: selection of the ideal technology for each separate case

Consultation of a geneticist before research and on the results.

Confidence in the health of your baby from the early stages of pregnancy!

NGC Clinic recommends all pregnant women to find out their fetal chromosomal set during the early period pregnancy by research of fetal DNA, though the blood of the mother without invasive interventions.

Geneticists in our Medical Center are first in St. Petersburg and Among the first in Russia to be using Prenatal practice in research of fetal chromosomes in a non-invasive way-through the fetal DNA in the mother’s blood.

DNA screening – research which is appointed in the early stages of pregnancy, is carried out non-invasively and without threats. Excludes the possibility of Down syndrome and other frequent chromosomal abnormalities.

The result will relieve you of long-term concern, give confidence in the health of the forthcoming baby.

The purpose for research of the fetal DNA

  • DNA screening eliminates the most frequent chromosomal disorders of the fetus – the following syndromes and ailments:
    • Down
    • Edwards
    • Patau
    • Shereshevskiy-Turner
    • Klinefelter
    • triploids
  • A DNA test detects the presence of microdeletions – the loss of small sections of chromosomes
  • According to research it is possible to eliminate abnormalities of the sex chromosomes, presence of triploids and ones numbered 21, 13, 18 with a probability of 99.7%
  • DNA test is an important research for the precise determination of sex of the fetus in case of gender-linked genetic afflictions

What is the research technology based on?

  • Unique research proved that blood of pregnant women contains a significant percentage of fetal DNA - upto 25%
  • fetal DNA can be isolated and studied
  • Molecular genetic research of fetal DNA allows us to estimate the number of chromosomes of the fetus and eliminate the fluctuation in their numbers, which leads to Down's syndrome, Edwards, Patau, Turner and other syndromes
  • expanded research allows to avoid random loss of genetic material - microdeletion and in other chromosomes

Testing can be done from 9th week of pregnancy through the mother’s blood, in which there is already a sufficient amount of the fetal DNA. The study of fetal DNA has been used in the world for a while now, but only since 2011 it has become possible to carry out research with high precision and therefore to strongly recommend it to all pregnant women.

Comparison of the effectiveness of the algorithm of conventional prenatal diagnosis and non-invasive testing - DNA screening to detect fetal chromosomal pathologies.
Conventional algorithm
  • Ultrasonography at 12th week
  • BS (Biochemical Screening)”Double test”-DNA screening at 9th week The results of which are available only by the 14th week of pregnancy
  • If increased risk, ultrasound at 20th week
  • Invasive diagnosis (puncturing)
With the use of DNA screening
  • Ultrasonography at 9th week
  • DNA screening at 9th week
screening tests evaluate only indirect signs of chromosomal pathologies
Direct research of the fetal genetic structure (DNA) the precision of 99.99%
chromosomal and other pathologies are eliminated only by the 22nd week of pregnancy
Possibility to eliminate Down’s syndrome and other chromosomal pathologies by the 11th week of of pregnancy

Important: The conventional algorithm allows to reveal most of the cases of Down's syndrome, but not all.

Good ultrasound data and biochemical screening can not eliminate chromosomal abnormalities of the fetus as they do not examine the genetic structure (chromosome or DNA)

What types of non-invasive testing exist?

Currently, there are various testing technology in use - quantitative analysis of general DNA, research with the identification of fetal DNA, estimation of the number of chromosomes, the exclusion of microdeletions etc. Some technologies are only used during singleton pregnancy, others - at double pregnancy. There certain features during pregnancy after IVF, especially in the case of donor programs and surrogacy. We cooperate with leading laboratories in the world in the field of non-invasive testing - Natera (Panorama) and Ariosa (Harmony).

A physician-geneticist will help you understand which test will be the best suited in you case. The best and optimal research technology will be picked for Your case from the results of medic and genetic consulting.

Non-invasive testing - DNA Screening, to whom and when can it be assigned?

The study of fetal DNA can be carried out from 9th week of pregnancy. Duration of pregnancy - the "age of our patient' needs to be confirmed by ultrasound and has to be at least 2.5 cm.

DNA screening is recommended for nearly all pregnant women - absolutely everyone has the risk of chromosomal pathology. The test is appointed before the ultrasound screening during the first trimester. Conducting a DNA screening removes the necessity of biochemical screening. Receiving the results only ultrasound screenings are appointed.

DNA screening is highly recommended during pregnancy after IVF.

The importance of non-invasive testing

Child health and complete safety of the mother - are two of the most important criteria for DNA screening. At high risk of loss of pregnancy and the inability to carry out invasive diagnostics ( a threat of pregnancy termination, mother has an infection, etc.) DNA Screening is the only way to find out the chromosome set of the fetus.

“Modern high-precision technologies - for every child! We will be glad to help each and every family!”

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Saint-Petersburg

13th line of Vasilevsky Island, 10
Vasileostrovskaya station

8 (812) 77 55555

Moscow

Verkhnyaya Krasnoselskaya, 3/3
Krasnoselskaya

7 (495) 111 0909

Success stories

The entire staff was fantastic. Many speak English. My husband & I went twice this last summer from Dallas, T.X. and the second time I came home pregnant

Tammy Isbell, 31 October

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Enormous Spasibo about the doctor Lobzeva Diana Andreevna!

Stella, 27 October

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Me and my husband want to thank Diana Lobzeva and NGC clinic for their assistance

Nataša, 27 October

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