Saint-Petersburg

13th line of Vasilevsky Island, 10
Vasileostrovskaya station

Moscow

Verkhnyaya Krasnoselskaya, 3/3
Krasnoselskaya

8 (812) 77 55555

7 (495) 11 10909

News of the clinic

Last news of the REPRODUCTION MEDICINE
30 August

NextGen carrier screening – way to succesful and healthy pregnancy

NextGen carrier screening – way to succesful and healthy pregnancy

Health of the children - is the greatest value. But for all parents, even completely healthy ones , there is a possibility to bear a child with hereditary disease caused by mutations in genes. Each of us is bearer of several hereditary diseases. The danger arises, when both parents have a mutation in a single gene, and transmit them to their child. NextGen (Next Generation Carrier Screening) allows a comprehensive study of the genes based on a technology highly efficient sequencing - which allows all future parents in advance to find out their genetic status and to evaluate the risk of giving birth to seriously ill children . The unique test is the result of joint work by NGC clinic and ParSeq Lab (St. Petersburg). This analysis enables to identify clinically significant variations of inherited disease in the genes - especially the most frequent and severe, which can lead to early death or significant deterioration of the quality of life.

Gene
Disease
Inheritance
CFTR
Cystic fibrosis
AR
PAH
Phenylketonuria
AR
SMN1
Spinal muscular atrophy
AR
SMN2DMPK
Myotonic dystrophy type I
AR
DMD
Duchenne muscular dystrophy
X-linked
HTT
Huntington's Disease
AD
F8
Hemophilia A
X-linked
HBB
Beta-thalassemia
AP
HBB
Sickle cell anemia
AR
APC
Familial Adenomatous Polyposis type I and II
AD
MUTYH
Familial Adenomatous Polyposis type I and II
AR
IDUA
Mucopolysaccharidosis type I
AR
PKD1
Autosomal dominant polycystic kidney disease type I and II
AD
PKD2 AD PMP22
disease Charcot-Marie-Tooth
AD
VHL
disease Von Hippel - Lindau
AD
ATP7B
Wilson's disease
AR
GBA
Gaucher disease
AR
HEXA
Tay - Sachs
AR
BRCA1
Hereditary breast cancer and ovarian I and II
AD
BRCA2
Hereditary breast cancer and ovarian I and II
AD
AR - autosomal recessive; AD - autosomal dominant.

To whom NextGen recommened to?

Everyone. Especially:

  • those who are planning the birth of a child
  • If you have a family history of hereditary diseases
  • If family’s  history of hereditary diseases is unknown
  • in the case of consanguineous marriage
  • ethnic groups with an increased risk
  • when planning IVF with a donor
  • all donors in the program of assisted reproduction

NGC Clinic will help you to choose a donor of gametes with a known genetic status who has been examined using the NextGen test.

NextGen test - technology and capabilities

  • based on highly efficient sequencing technology (NGS)
  • aims to establish carrier status of the most often occurring and severe hereditary diseases
  • identifies both known and previously described mutations, including genes with high population heterogeneity - familial cases
  • has high analytical characteristics(Sensitivity 99% and specificity 99%)
  • allows to determine the genetic status of the studied genes with a high degree of accuracy
  • assigned once and is relevant for each subsequent pregnancy

Use of the  NextGen test will allow you to significantly reduce the likelihood of  birth of children with severe hereditary diseases.

Based on research the  doctor geneticist calculates the reproductive risk and develops recommendations for each individual family.

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Book a consultation
Saint-Petersburg

13th line of Vasilevsky Island, 10
Vasileostrovskaya station

8 (812) 77 55555

Moscow

Verkhnyaya Krasnoselskaya, 3/3
Krasnoselskaya

7 (495) 11 10909

Success stories

Thanks Russia for hospitality and their experience in IVF treatment

Cris, 01 August

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